Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6748270 | 0.90 | ACHE (0.32) | GPR3ACHE | |
| Hydrochloric Acid SCHEMBL4959303 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL153468 | 0.78 | CYP1A2 (0.41) | SLC6A4SLC6A3GPR3CYP1A2CYP2D6 | |
| Fluoride Ion SCHEMBL1130361 | 0.74 | CYP1A2 (0.45) | SLC6A4SLC6A3GPR3CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL6555618 | 0.73 | GPR3 (0.31) | GPR3 | |
| Hydrochloric Acid SCHEMBL6558844 | 0.71 | CYP2D6 (0.33) | CYP1A2CYP2D6BCHEACHE | |
| Hydrochloric Acid SCHEMBL6433415 | 0.70 | DRD2 (0.32) | GPR3CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL651332 | 0.69 | ACHE (0.32) | GPR3CYP1A2CYP2D6BCHEACHE | |
| Hydrochloric Acid SCHEMBL650587 | 0.69 | ACHE (0.32) | GPR3CYP1A2CYP2D6BCHEACHE | |
| Hydrochloric Acid SCHEMBL6061204 | 0.69 | ACHE (0.33) | BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583237-B1 | Silyl-terminated olefin polymers; catalyst is transition metal cyclopentadiene compound, organoaluminum oxycompound, compounds that form an ion pair, organoaluminum compound, organosilicon compound, a dialkylzinc compound, and hydrogen | MITSUI CHEMICALS, INC. (JP) | 2003-06-24 | — | — | US | disclosed |
| US-6297333-B1 | METALLOCENE TRANSITION METAL COMPOUND HAVING AN INDENYL GROUP AND A FLUORENYL GROUP AS LIGANDS, SPECIFIC SUBSTITUENT ON A SPECIFIC POSITION OF THE INDENYL GROUP GIVES HIGH MOLECULAR WEIGHT AND HIGH ACTIVITY | MITSUI CHEMICALS INC (JP) | 2001-10-02 | — | — | US | disclosed |
| EP-1092730-A1 | PROCESS FOR PRODUCING OLEFIN POLYMER AND OLEFIN POLYMER | Mitsui Chemicals, Inc. (JP) | 2001-04-18 | — | — | EP | disclosed |
| US-6004897-A | TRANSITION METAL INDENE-FLUORINE COMPLEX COORDINATION CATALYST WITH ORGANOALUMINUM AND ALUMOXANE COMPOUNDS | MITSUI CHEMICALS, INC. (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0754698-A2 | An olefin polymerization catalyst and a process for preparing olefin polymer | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-22 | — | — | EP | disclosed |