Phosphoric Acid

SCHEMBL7195772

Cc1cccc([P+](Cc2cc([N+](=O)[O-])cc([N+](=O)[O-])c2)(c2cccc(C)c2)c2cccc(C)c2)c1.Cc1cccc([P+](Cc2cc([N+](=O)[O-])cc([N+](=O)[O-])c2)(c2cccc(C)c2)c2cccc(C)c2)c1.Cc1cccc([P+](Cc2cc([N+](=O)[O-])cc([N+](=O)[O-])c2)(c2cccc(C)c2)c2cccc(C)c2)c1.O=P([O-])([O-])[O-]

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3 CYP11B1 DPP4 FGFR1 FGFR2 FGFR3 FGFR4 HRH1 JAK1 JAK2 JAK3 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KDR KIT NA OPRD1 OPRK1 OPRM1 P PDGFRB PIK3CD SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SMO TYK2 pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	TSHR	P16473	4/20	0.46

▸	ACHE	P22303	1/20	0.46

▸	ALOX5	P09917	2/20	0.43

▸	MEN1	O00255	3/20	0.38

▸	KMT2A	Q03164	3/20	0.38

▸	MAPT	P10636	2/20	0.38

▸	LMNA	P02545	2/20	0.38

▸	CYP1A2	P05177	1/20	0.36

▸	CYP3A4	P08684	1/20	0.36

▸	CYP2C19	P33261	1/20	0.36

▸	L3MBTL1	Q9Y468	1/20	0.36

▸	GRM8	O00222	1/20	0.36

▸	GRM6	O15303	1/20	0.36

▸	GRM4	Q14833	1/20	0.36

▸	ACP3	P15309	1/20	0.35

▸	CA12	O43570	1/20	0.35

▸	CA1	P00915	1/20	0.35

▸	MMP2	P08253	1/20	0.35

▸	PTPRC	P08575	1/20	0.35

▸	SMN1; SMN2	Q16637	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Phosphoric Acid SCHEMBL7195789	0.96	TSHR (0.45)	TSHRACHEALOX5MEN1KMT2A
Iodide SCHEMBL7197607	0.93	TSHR (0.50)	TSHRACHEALOX5MEN1KMT2A
Bromide SCHEMBL7194050	0.93	TSHR (0.50)	TSHRACHEALOX5MEN1KMT2A
Hydrochloric Acid SCHEMBL7199844	0.93	TSHR (0.50)	TSHRACHEALOX5MEN1KMT2A
Acetic Acid SCHEMBL8750071	0.90	TSHR (0.46)	TSHRACHEALOX5MEN1KMT2A
Acetic Acid SCHEMBL7195843	0.87	ALOX5 (0.44)	TSHRACHEALOX5MEN1KMT2A
Succinic Acid SCHEMBL7195837	0.86	ALOX5 (0.43)	TSHRACHEALOX5MEN1KMT2A
Phosphoric Acid SCHEMBL7194313	0.85	ACHE (0.43)	TSHRACHEMEN1KMT2AMAPT
Phosphoric Acid SCHEMBL7197899	0.80	ACP3 (0.43)	MAPTLMNAACP3RAB9A
Phosphoric Acid SCHEMBL7197978	0.80	RAB9A (0.40)	ACHEMEN1KMT2AACP3SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0624173-B2	PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS	DOW CHEMICAL CO (US)	2003-04-09	—	—	EP	disclosed
EP-0624173-B1	PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS	DOW CHEMICAL CO (US)	1997-04-02	—	—	EP	disclosed
EP-0624173-A1	PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS.	DOW CHEMICAL CO (US)	1994-11-17	—	—	EP	disclosed
US-5360886-A	Alklyphenylphosphine or phosphonium catalyst	THE DOW CHEMICAL COMPANY (US)	1994-11-01	—	—	US	disclosed
US-5310853-A	Epoxy resins	THE DOW CHEMICAL COMPANY (US)	1994-05-10	—	—	US	disclosed
WO-1993015126-A1	PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS	THE DOW CHEMICAL COMPANY (US)	1993-08-05	—	—	WO	disclosed
US-5202407-A	Phosphonium or phosphine catalyst having at least three alkylphenyl groups attached to phosphorus atom	THE DOW CHEMICAL COMPANY (US)	1993-04-13	—	—	US	disclosed