SCHEMBL7196034

SCHEMBL7196034

Cc1cccc(C(=O)O)c1COc1ccc2nc(C)n(C(C)c3ncc(C(F)(F)F)cc3Cl)c2c1

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 3/20 0.41
PPARG P37231 3/20 0.40
NR1H4 Q96RI1 8/20 0.39
VDR P11473 6/20 0.39
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
MAPK1 P28482 1/20 0.37
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7196037 0.82 PPARG (0.41) MRGPRX4PPARGNR1H4MEN1KMT2A
SCHEMBL6920283 0.81 FFAR4 (0.41) MEN1KMT2AMAPK1
SCHEMBL7169900 0.77 NR1H4 (0.35) PPARGNR1H4VDR
SCHEMBL7196025 0.76 MAPK1 (0.36) MEN1KMT2AMAPK1POLB
SCHEMBL7192439 0.74 MRGPRX4 (0.40) MRGPRX4MEN1KMT2APOLB
SCHEMBL6488591 0.72 ALOX5AP (0.44) PPARG
SCHEMBL7196721 0.72 PPARG (0.46) MRGPRX4PPARG
SCHEMBL7191530 0.71 AGTR1 (0.40) MRGPRX4MEN1KMT2APOLB
SCHEMBL6922932 0.70 MAPK1 (0.41) MEN1KMT2AMAPK1
SCHEMBL31568416 0.67 MRGPRX4 (0.58) MRGPRX4MAPK1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004108686-A2 BENZIMIDAZOLE COMPOUNDS HAVING HYPOGLYCEMIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-12-16 WO disclosed