Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD4 | P21917 | 5/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CCL2 | P13500 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7199653 | 0.96 | DRD2 (0.40) | DRD2DRD4BRD4CCL2CYP19A1 | |
| Hydrochloric Acid SCHEMBL7195319 | 0.75 | LMNA (0.33) | — | |
| Hydrochloric Acid SCHEMBL7183660 | 0.73 | DRD2 (0.44) | DRD2DRD4BRD4CCL2CYP19A1 | |
| Hydrochloric Acid SCHEMBL32685441 | 0.73 | DRD2 (0.44) | DRD2DRD4BRD4CCL2CYP19A1 | |
| Hydrochloric Acid SCHEMBL8665926 | 0.72 | DRD2 (0.39) | DRD2DRD4BRD4CCL2CYP19A1 | |
| Hydrochloric Acid SCHEMBL6129924 | 0.72 | DRD2 (0.39) | DRD2DRD4BRD4CCL2CYP19A1 | |
| Hydrochloric Acid SCHEMBL812517 | 0.72 | DRD2 (0.39) | DRD2DRD4BRD4CCL2CYP19A1 | |
| Hydrochloric Acid SCHEMBL27933029 | 0.72 | DRD2 (0.39) | DRD2DRD4BRD4CCL2CYP19A1 | |
| Hydrochloric Acid SCHEMBL27948813 | 0.72 | DRD2 (0.39) | DRD2DRD4BRD4CCL2CYP19A1 | |
| Hydrochloric Acid SCHEMBL7197803 | 0.72 | CYP3A4 (0.40) | DRD2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668865-B1 | INDENYL COMPOUNDS AND CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS | DSM NV (NL) | 2003-07-23 | — | — | EP | disclosed |
| US-5990253-A | METALLOCENES HAVING THE INDENE RING BINDING AT THE 2-POSITION RATHER THAN AT THE 1-POSITION; COORDINATION CATALYSTS; LESS CRYSTALLIZATION IN THE ADDITION POLYMERIZATION OF ELASTOMERS | DSM N.V. (NL) | 1999-11-23 | — | — | US | disclosed |
| US-5646322-A | Indenyl compounds and catalyst components for the polymerization of olefins | DSM N.V. (NL) | 1997-07-08 | — | — | US | disclosed |
| EP-0668865-A1 | INDENYL COMPOUNDS AND CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS | DSM N.V. (NL) | 1995-08-30 | — | — | EP | disclosed |
| WO-1994011406-A1 | INDENYL COMPOUNDS AND CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS | DSM N.V. (NL) | 1994-05-26 | — | — | WO | disclosed |