SCHEMBL7197331

SCHEMBL7197331

CCOC(=S)SC(=O)C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
CYP2D6 P10635 1/20 0.50
HDAC4 P56524 4/20 0.37
HDAC6 Q9UBN7 4/20 0.37
HDAC3 O15379 3/20 0.37
HDAC1 Q13547 3/20 0.37
HDAC7 Q8WUI4 2/20 0.37
HDAC2 Q92769 2/20 0.37
HDAC10 Q969S8 2/20 0.37
HDAC11 Q96DB2 2/20 0.37
HDAC8 Q9BY41 2/20 0.37
HDAC9 Q9UKV0 2/20 0.37
HDAC5 Q9UQL6 2/20 0.37
LMNA P02545 1/20 0.34
HSD17B10 Q99714 1/20 0.34
MAPT P10636 3/20 0.34
GAA P10253 2/20 0.33
PKM P14618 2/20 0.33
CA12 O43570 2/20 0.33
CA1 P00915 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20582654 0.79 ALDH1A1 (0.39) ALDH1A1CYP2D6HDAC4HDAC6HDAC3
SCHEMBL1904872 0.77 ALDH1A1 (0.61) ALDH1A1CYP2D6HDAC4HDAC6HDAC3
SCHEMBL3588443 0.75 ALDH1A1 (0.50) ALDH1A1CYP2D6HDAC4HDAC6HDAC3
SCHEMBL10963692 0.74 ALDH1A1 (0.52) ALDH1A1CYP2D6HDAC4HDAC6HDAC3
SCHEMBL8844675 0.74
SCHEMBL27768690 0.72 ALDH1A1 (0.50) ALDH1A1CYP2D6HDAC4HDAC6HDAC3
SCHEMBL31694248 0.70 ALDH1A1 (0.42) ALDH1A1CYP2D6HDAC4HDAC6HDAC3
SCHEMBL28393816 0.69 ALDH1A1 (0.47) ALDH1A1CYP2D6HDAC4HDAC6HDAC3
SCHEMBL2445178 0.68 ALDH1A1 (0.59) ALDH1A1CYP2D6HDAC4HDAC6HDAC3
SCHEMBL4254370 0.68 ALDH1A1 (0.46) ALDH1A1CYP2D6HDAC4HDAC6HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1528722-A Perfluoro alkylated derivative ���ɡ����ʿ˻�ѧ��˾ 2004-09-15 CN disclosed
US-6506286-B1 Photolytic decarbonylation direct radical conversion of such as a perhalogenated thioester to a perhalogenated thioether RHODIA CHIMIE (FR) 2003-01-14 US disclosed
US-6156163-A Reactant, compound and process for the perfluoroalkylation of the nucleophile, and the derivatives obtained RHODIA CHIMIE (FR) 2000-12-05 US disclosed
CN-1179148-A Nucleophile perfluoroalkylation reagents, compounds and methods and derivatives obtained RHONE POULENC CHIMIE (FR) 1998-04-15 CN disclosed