SCHEMBL7199024

SCHEMBL7199024

Nc1ccc(S(=O)(=O)c2ccc(N)c(C(F)(F)F)c2)cc1

nearest known ligand 0.62

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 3/20 0.62
ALDH1A1 P00352 2/20 0.62
PKM P14618 1/20 0.62
LMNA P02545 2/20 0.55
MPO P05164 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2C9 P11712 1/20 0.55
TSHR P16473 1/20 0.55
FFAR4 Q5NUL3 11/20 0.49
FFAR1 O14842 3/20 0.48
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
NPC1 O15118 1/20 0.44
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2810971 0.93 FFAR4 (0.54) HTR6ALDH1A1PKMLMNAMPO
SCHEMBL7195357 0.85 LMNA (0.62) HTR6ALDH1A1PKMLMNATSHR
SCHEMBL10036536 0.84 HTR6 (0.56) HTR6ALDH1A1PKMLMNAMPO
SCHEMBL7187838 0.84 FFAR4 (0.45) HTR6ALDH1A1PKMLMNAMPO
SCHEMBL16906999 0.83 MEN1 (0.53) HTR6ALDH1A1PKMLMNAMPO
SCHEMBL7192533 0.83 FFAR4 (0.44) HTR6ALDH1A1PKMLMNAMPO
SCHEMBL20468361 0.81 LMNA (0.45) HTR6ALDH1A1PKMLMNAMPO
SCHEMBL10389017 0.81 FFAR4 (0.49) LMNAFFAR4FFAR1
SCHEMBL11685070 0.80 CA12 (0.58) PKMFFAR4FFAR1MEN1KMT2A
SCHEMBL652562 0.79 FFAR4 (0.51) HTR6ALDH1A1PKMFFAR4FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144358-A3 PROCESS FOR PRODUCTION OF 2-AMINO-1,3-PROPANEDIOL ABBOTT LABORATORIES (US) 2002-08-28 EP claimed
EP-1144358-A2 PROCESS FOR PRODUCTION OF 2-AMINO-1,3-PROPANEDIOL ABBOTT LABORATORIES (US) 2001-10-17 EP claimed
WO-2000015600-A2 PROCESS FOR PRODUCTION OF 2-AMINO-1,3-PROPANEDIOL ABBOTT LABORATORIES (US) 2000-03-23 WO claimed
US-11692062-B2 Methods of manufacture for polyetherimide SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2023-07-04 US disclosed
EP-3562858-A1 METHODS OF MANUFACTURE FOR POLYETHERIMIDE SABIC Global Technologies B.V. (NL) 2019-11-06 EP disclosed
US-20190309127-A1 METHODS OF MANUFACTURE FOR POLYETHERIMIDE SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2019-10-10 US disclosed
WO-2018126007-A1 METHODS OF MANUFACTURE FOR POLYETHERIMIDE SABIC GLOBAL TECHNOLOGIES B. V. (NL) 2018-07-05 WO disclosed
US-20030064235-A1 Optical members made of polymide resins MITSUI CHEMICALS, INC. (JP) 2003-04-03 US disclosed