Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6916246 | 0.70 | CA1 (0.41) | ALDH1A1KDM4EHSD17B10SMN1; SMN2PKM | |
| SCHEMBL8691849 | 0.68 | PTGS2 (0.49) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8639171 | 0.68 | ALOX5 (0.50) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5169740 | 0.66 | CYP2C9 (0.45) | ALDH1A1HPGDSMN1; SMN2PKMCA1 | |
| SCHEMBL1094344 | 0.66 | ALDH1A1 (0.59) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9400074 | 0.65 | CA1 (0.52) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL2084284 | 0.65 | ATM (0.51) | ALDH1A1KDM4EPOLBHTR6CA1 | |
| SCHEMBL8639257 | 0.65 | ADRA2A (0.42) | TSHRALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL21863518 | 0.64 | — | — | |
| SCHEMBL16720110 | 0.64 | CA1 (0.50) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283833-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001090091-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2001-11-29 | — | — | WO | disclosed |