Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DDX3X | O00571 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8750044 | 0.94 | ALDH1A1 (0.40) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| Acetic Acid SCHEMBL7199760 | 0.91 | ALDH1A1 (0.39) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| Bromide SCHEMBL7199727 | 0.90 | MAPT (0.39) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| Iodide SCHEMBL7194039 | 0.90 | MAPT (0.39) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL7192434 | 0.90 | MAPT (0.39) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| Phosphoric Acid SCHEMBL7197564 | 0.86 | MAPT (0.38) | ALDH1A1LMNASMN1; SMN2MAPTNPC1 | |
| Succinic Acid SCHEMBL7196996 | 0.81 | HDAC3 (0.47) | ALDH1A1SMN1; SMN2MAPTL3MBTL1NPC1 | |
| Succinic Acid SCHEMBL7201382 | 0.80 | ACHE (0.40) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| Succinic Acid SCHEMBL7195837 | 0.79 | ALOX5 (0.43) | ALDH1A1SMN1; SMN2MAPTNPC1ALOX5 | |
| Succinic Acid SCHEMBL7195814 | 0.79 | HDAC3 (0.38) | ALDH1A1SMN1; SMN2L3MBTL1NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624173-B2 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS | DOW CHEMICAL CO (US) | 2003-04-09 | — | — | EP | disclosed |