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Phosphoric Acid

Phosphoric Acid

SCHEMBL7199855

Cc1ccc([P+](CCCO)(c2ccc(C)cc2)c2ccc(C)cc2)cc1.Cc1ccc([P+](CCCO)(c2ccc(C)cc2)c2ccc(C)cc2)cc1.Cc1ccc([P+](CCCO)(c2ccc(C)cc2)c2ccc(C)cc2)cc1.O=P([O-])([O-])[O-]

nearest known ligand 0.40

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 2/20 0.40
▸ LMNA P02545 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ CA12 O43570 2/20 0.37
▸ CA1 P00915 1/20 0.37
▸ MMP8 P22894 1/20 0.37
▸ MMP2 P08253 1/20 0.37
▸ CA9 Q16790 1/20 0.37
▸ CA14 Q9ULX7 1/20 0.37
▸ FDFT1 P37268 1/20 0.36
▸ RECQL P46063 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ PGK1 P00558 1/20 0.32
▸ PGK2 P07205 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ CYP3A4 P08684 1/20 0.32
▸ CYP2C9 P11712 1/20 0.32
▸ CYP2C19 P33261 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ GGPS1 O95749 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7194031 0.89 HIF1A (0.34) GAALMNATSHRALDH1A1CYP2C19
Bromide SCHEMBL7194017 0.89 HIF1A (0.34) GAALMNATSHRALDH1A1CYP2C19
Iodide SCHEMBL7197154 0.89 HIF1A (0.34) GAALMNATSHRALDH1A1CYP2C19
Acetic Acid SCHEMBL8750056 0.88 STAT3 (0.35) LMNATSHRRECQLSMN1; SMN2ALDH1A1
Succinic Acid SCHEMBL7192904 0.85 ALDH1A1 (0.36) TSHRCA1ALDH1A1CYP2C19
Acetic Acid SCHEMBL7192906 0.85 ALDH1A1 (0.36) GAATSHRSMN1; SMN2ALDH1A1CYP2C19
Phosphoric Acid SCHEMBL9067729 0.81 FDFT1 (0.38) GAALMNATSHRCA12CA1
Phosphoric Acid SCHEMBL7198172 0.80 ACP3 (0.40) GAAMMP8MMP2PGK1PGK2
Phosphoric Acid SCHEMBL7193240 0.77 LMNA (0.40) GAALMNATSHRCA12CA1
Phosphoric Acid SCHEMBL7196602 0.74 FDFT1 (0.41) GAALMNATSHRCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0624173-B2 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS DOW CHEMICAL CO (US) 2003-04-09 — — EP disclosed
EP-0624173-B1 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS DOW CHEMICAL CO (US) 1997-04-02 — — EP disclosed
EP-0624173-A1 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS. DOW CHEMICAL CO (US) 1994-11-17 — — EP disclosed
US-5360886-A Alklyphenylphosphine or phosphonium catalyst THE DOW CHEMICAL COMPANY (US) 1994-11-01 — — US disclosed
US-5310853-A Epoxy resins THE DOW CHEMICAL COMPANY (US) 1994-05-10 — — US disclosed
WO-1993015126-A1 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS THE DOW CHEMICAL COMPANY (US) 1993-08-05 — — WO disclosed
US-5202407-A Phosphonium or phosphine catalyst having at least three alkylphenyl groups attached to phosphorus atom THE DOW CHEMICAL COMPANY (US) 1993-04-13 — — US disclosed