Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.33 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL720542 | 0.90 | CYP2C19 (0.37) | TP53CYP2C19KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL720005 | 0.87 | CYP2C19 (0.35) | TP53CYP2C19KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL720495 | 0.79 | TEAD4 (0.34) | KMT2AHSD17B10MAPTMEN1ABL1 | |
| SCHEMBL719968 | 0.79 | NPC1 (0.38) | TP53KMT2AHSD17B10ALDH1A1MAPT | |
| SCHEMBL719479 | 0.77 | GCG (0.46) | KMT2AHSD17B10ALDH1A1MAPTHPGD | |
| SCHEMBL716552 | 0.76 | NPC1 (0.40) | TP53CYP2C19KMT2AALDH1A1MAPT | |
| SCHEMBL721467 | 0.74 | SSTR4 (0.35) | HSD17B10ALDH1A1HTTABL1RIN1 | |
| SCHEMBL3402542 | 0.73 | CASP3 (0.37) | KMT2AALDH1A1MAPTMEN1NPC1 | |
| SCHEMBL719271 | 0.73 | OPRM1 (0.41) | ABL1RIN1HDAC6SLC6A2OPRM1 | |
| SCHEMBL720995 | 0.73 | TSHR (0.39) | TP53KMT2AALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053173-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053173-A1 | HETEROCYCLIC COMPOUND | SLC5A2, SLC5A1, IAPP | TP53 293/4885CYP2C19 946/4885KMT2A 1298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.