Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5278958 | 0.88 | ALDH1A1 (0.75) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL2470335 | 0.88 | ALDH1A1 (0.75) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| Alcohol SCHEMBL7030010 | 0.88 | ALDH1A1 (0.68) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL238953 | 0.88 | THRB (0.70) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL9577936 | 0.86 | ALDH1A1 (0.78) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| Ethylene Glycol SCHEMBL10426882 | 0.86 | ALDH1A1 (0.66) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL22264522 | 0.86 | ALDH1A1 (0.78) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL134216 | 0.86 | ALDH1A1 (0.78) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| Formaldehyde SCHEMBL23716978 | 0.84 | ALDH1A1 (0.75) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| Propanol SCHEMBL7031961 | 0.84 | ALDH1A1 (0.63) | ALDH1A1TP53HIF1ACYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355994-A2 | RADIATION CURABLE COATING FOR THERMOPLASTIC SUBSTRATES | Valspar Sourcing, Inc. (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002077109-A2 | RADIATION CURABLE COATING FOR THERMOPLASTIC SUBSTRATES | VALSPAR SOURCING, INC. (US) | 2002-10-03 | — | — | WO | disclosed |