Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 15/20 | 0.63 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27445498 | 0.90 | ALOX5 (0.61) | ALOX5MTNR1ALTA4HPTPN1ALOX12 | |
| SCHEMBL7203574 | 0.87 | ALOX5 (0.66) | ALOX5MTNR1AALOX12PTGS1PTGS2 | |
| SCHEMBL7198793 | 0.87 | ALOX5 (0.66) | ALOX5MTNR1AALOX12PTGS1PTGS2 | |
| SCHEMBL9730115 | 0.83 | ALOX5 (0.64) | ALOX5MTNR1AALOX12 | |
| SCHEMBL7202165 | 0.81 | MTNR1A (0.62) | ALOX5MTNR1AALOX12PTGS1PTGS2 | |
| SCHEMBL27463101 | 0.81 | ALOX5 (0.55) | ALOX5MTNR1ALTA4HTHRATHRB | |
| SCHEMBL7199698 | 0.80 | MTNR1A (0.72) | ALOX5MTNR1AALOX12 | |
| SCHEMBL27445499 | 0.80 | ALOX5 (0.53) | ALOX5MTNR1ALTA4HPTPN1THRA | |
| SCHEMBL7204127 | 0.79 | MTNR1A (0.77) | ALOX5MTNR1AALOX12 | |
| SCHEMBL7202221 | 0.79 | ALOX5 (0.56) | ALOX5MTNR1ATHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602903-B2 | Substituted O- and/or S heterocyclic compounds; powerful ligands for melatoninergic receptors. | LES LABORATORIES SERVIER (FR) | 2003-08-05 | — | — | US | disclosed |
| US-20020052400-A1 | Substituted heterocyclic compounds | ADIR ET COMPAGNIE | 2002-05-02 | — | — | US | disclosed |
| US-6313160-B1 | FOR THERAPY AND PROPHYLAXIS OF MELATONINERGIC DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-11-06 | — | — | US | disclosed |
| EP-0998471-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS, METHOD FOR PREPARING AND COMPOSITIONS CONTAINING SAME | ADIR ET COMPAGNIE (FR) | 2000-05-10 | — | — | EP | disclosed |
| WO-1998052935-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS, METHOD FOR PREPARING AND COMPOSITIONS CONTAINING SAME | ADIR ET COMPAGNIE (FR) | 1998-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052400-A1 | Substituted heterocyclic compounds | MTNR1A, MTNR1B, CBR1 | ALOX5 567/4885MTNR1A 1/4885LTA4H 1440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.