Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | ADA | P00813 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962978 | 0.93 | PPARG (0.39) | KDM4ELTA4HSMN1; SMN2PRMT5WDR77 | |
| SCHEMBL7969551 | 0.92 | MEN1 (0.41) | LTA4HSMN1; SMN2PRMT5WDR77KMT2A | |
| SCHEMBL7953284 | 0.92 | PDE10A (0.40) | LTA4HDRD3PRMT5WDR77KMT2A | |
| SCHEMBL7953343 | 0.91 | ALDH1A1 (0.46) | LTA4HSMN1; SMN2DRD3KMT2AMEN1 | |
| SCHEMBL7969474 | 0.91 | MAPT (0.38) | LTA4HSMN1; SMN2DRD3PRMT5WDR77 | |
| SCHEMBL7953566 | 0.91 | OPRM1 (0.39) | MAPK1LTA4HSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7969307 | 0.90 | LTA4H (0.44) | LTA4HSMN1; SMN2HRH3PRMT5WDR77 | |
| SCHEMBL7953451 | 0.90 | LTA4H (0.38) | LTA4HDRD3PRMT5WDR77KMT2A | |
| SCHEMBL7965171 | 0.90 | DRD2 (0.41) | LTA4HDRD3KMT2AMEN1ALDH1A1 | |
| SCHEMBL7966948 | 0.90 | OPRM1 (0.39) | KDM4ELTA4HSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030004207-A1 | USE OF COMPOUNDS WHICH ACTIVATE A 5-HT RECEPTOR TO TREAT URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICALS CORPORATION | 2003-01-02 | — | — | US | disclosed |
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |