Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27398624 | 0.81 | MAPT (0.53) | TSHRNPSR1GAAMAPTGRIN2D | |
| SCHEMBL28787105 | 0.81 | MAPT (0.53) | TSHRNPSR1GAAMAPTGRIN2D | |
| SCHEMBL3732085 | 0.80 | TSHR (0.51) | TSHRNPSR1GAAMAPTGRIN2D | |
| SCHEMBL10331843 | 0.76 | TSHR (0.48) | TSHRNPSR1GAAMAPTSIGMAR1 | |
| SCHEMBL28296103 | 0.74 | GAA (0.49) | TSHRNPSR1GAAMAPTGRIN2D | |
| SCHEMBL1325110 | 0.73 | TSHR (0.48) | TSHRNPSR1ALDH1A1 | |
| SCHEMBL12500797 | 0.73 | MAPT (0.51) | TSHRNPSR1GAAMAPTGRIN2D | |
| SCHEMBL9608966 | 0.72 | TSHR (0.67) | TSHRNPSR1GAAMAPTALDH1A1 | |
| SCHEMBL17231978 | 0.72 | TSHR (0.67) | TSHRNPSR1GAAMAPTALDH1A1 | |
| SCHEMBL21689895 | 0.72 | TSHR (0.67) | TSHRNPSR1GAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608193-B2 | Forming an intermediate by reacting the support-bound amino-substituted-tetrahydroisoquinoline compound with a reagent; and cyclizatively cleaving support-bound amino-substituted-tetrahydroisoquinoline compound | THE PROCTER & GAMBLE COMPANY | 2003-08-19 | — | — | US | disclosed |
| US-6566524-B2 | Providing amino-substituted-tetrahydroisoquinoline-carboxylate attached to a solid support; reacting with sulfonyl chloride compound; cleaving intermediate from solid support to form an amino-tetrahydroisoquinoline-sulfonamide hydroxamic acid | THE PROCTER & GAMBLE CO. | 2003-05-20 | — | — | US | disclosed |
| US-20020077480-A1 | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds | PROCTER & GAMBLE COMPANY, THE | 2002-06-20 | — | — | US | disclosed |
| US-20020058815-A1 | Methods for synthesis of amino-tertahydroisoquinoline-sulfonamide hydroxamic acids | PROCTER & GAMBLE COMANY, THE | 2002-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077480-A1 | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds | ASNS, QPCT, DAO | TSHR 4338/4885NPSR1 3091/4885GAA 2987/4885 |
| US-20020058815-A1 | Methods for synthesis of amino-tertahydroisoquinoline-sulfonamide hydroxamic acids | ASNS, GLUL, STS | TSHR 668/4885NPSR1 1904/4885GAA 1121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.