SCHEMBL7202579

SCHEMBL7202579

N#CC(C(=O)c1c(Cl)c(Cl)c(C(=O)C(C#N)c2ccccc2)c(Cl)c1Cl)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
TRPA1 O75762 1/20 0.38
LMNA P02545 6/20 0.37
ALDH1A1 P00352 4/20 0.37
USP2 O75604 1/20 0.37
HPGD P15428 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
AKR1C3 P42330 1/20 0.37
AKR1C1 Q04828 1/20 0.37
CYP2D6 P10635 1/20 0.36
SRC P12931 1/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7203037 0.95 TSHR (0.41) TSHRTDP1L3MBTL1TRPA1LMNA
SCHEMBL7199028 0.88 S1PR3 (0.36) TSHRTDP1L3MBTL1TRPA1LMNA
SCHEMBL7202991 0.81 LMNA (0.43) TSHRTDP1L3MBTL1TRPA1LMNA
SCHEMBL7202862 0.79 L3MBTL1 (0.55) TSHRTDP1L3MBTL1TRPA1LMNA
SCHEMBL5505530 0.79 L3MBTL1 (0.61) TSHRTDP1L3MBTL1TRPA1LMNA
SCHEMBL7196088 0.79 TSHR (0.47) TSHRTDP1L3MBTL1TRPA1LMNA
SCHEMBL7196084 0.79 LMNA (0.42) TSHRTDP1L3MBTL1TRPA1LMNA
SCHEMBL19926126 0.79 CES2 (0.47) TSHRTDP1L3MBTL1TRPA1LMNA
SCHEMBL2211558 0.77 TSHR (0.48) TSHRTDP1L3MBTL1TRPA1LMNA
SCHEMBL10961231 0.77 L3MBTL1 (0.43) TSHRTDP1L3MBTL1TRPA1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003042148-A2 PROCESS FOR PRODUCING BISBENZIL COMPOUNDS SHOWA DENKO K. K. (JP) 2003-05-22 WO disclosed