Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204598 | 0.87 | MAPT (0.51) | CTSLCTSSCTSKCTSBMMP9 | |
| SCHEMBL7205866 | 0.85 | CTSS (0.47) | CTSLCTSSCTSKCTSBMMP9 | |
| SCHEMBL7205858 | 0.85 | CTSS (0.47) | CTSLCTSSCTSKCTSBMMP9 | |
| SCHEMBL7209769 | 0.85 | CCKBR (0.45) | CTSLCTSSCTSKCTSBMMP9 | |
| Hydrochloric Acid SCHEMBL7203618 | 0.82 | MMP9 (0.47) | MMP9MMP8MMP14ITGA4PYGL | |
| Hydrochloric Acid SCHEMBL7203630 | 0.82 | MMP9 (0.47) | MMP9MMP8MMP14ITGA4PYGL | |
| SCHEMBL7202877 | 0.82 | MMP9 (0.41) | CTSLCTSSCTSKCTSBMMP9 | |
| SCHEMBL14513403 | 0.80 | MMP9 (0.63) | MMP9MMP8MMP14KMT2ATDP1 | |
| SCHEMBL5587642 | 0.80 | MMP9 (0.63) | MMP9MMP8MMP14KMT2ATDP1 | |
| SCHEMBL7204513 | 0.79 | CTSS (0.41) | CTSLCTSSCTSKCTSBMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921122-B1 | EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2003-05-21 | — | — | EP | disclosed |
| US-6110967-A | USEFUL AS AGENTS FOR PREVENTING AND TREATING METABOLIC OSTEOPATHY SUCH AS OSTEOPOROSIS, HYPERCALCEMIA AND BONE METASTASIS OF CANCER BECAUSE THEY SPECIFICALLY INHIBITS CATHEPSIN L AND ITS FAMILY ENZYMES TO INHIBIT BONE RESORPTION | TAIHO PHARMACEUTICALS CO., LTD. (JP) | 2000-08-29 | — | — | US | disclosed |