Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7206567 | 0.74 | ACP1 (0.52) | ALDH1A1KDM4EAURKAGAACYP1A2 | |
| SCHEMBL7202162 | 0.73 | AURKA (0.45) | AURKA | |
| SCHEMBL7204767 | 0.73 | JAK1 (0.56) | KDM4EHTTSMN1; SMN2AURKAKMT2A | |
| SCHEMBL5308810 | 0.73 | AURKA (0.62) | ALDH1A1KDM4EHTTNPC1RAB9A | |
| SCHEMBL7203775 | 0.72 | JAK1 (0.49) | AURKA | |
| SCHEMBL7200373 | 0.72 | ACP1 (0.55) | ALDH1A1KDM4EHTTNPC1HPGD | |
| SCHEMBL7201841 | 0.71 | AURKA (0.43) | ALDH1A1KDM4EHTTSMN1; SMN2AURKA | |
| SCHEMBL7199711 | 0.69 | JAK1 (0.52) | AURKA | |
| SCHEMBL20040367 | 0.69 | AURKA (0.69) | ALDH1A1KDM4EHTTNPC1HPGD | |
| SCHEMBL14796713 | 0.69 | FGFR1 (0.60) | ALDH1A1KDM4EHTTNPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605617-B2 | Treating a patient in need of an inhibitor of vascular endothelial growth factor receptor tyrosine kinase | CHIRON CORPORATION | 2003-08-12 | — | — | US | disclosed |