Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203775 | 0.84 | JAK1 (0.49) | JAK1KCNH2AURKAOPRM1OPRK1 | |
| SCHEMBL7199711 | 0.79 | JAK1 (0.52) | JAK1AURKA | |
| SCHEMBL4309421 | 0.75 | CNR1 (0.58) | JAK1MAPTKCNH2MCHR1ROCK2 | |
| SCHEMBL7206567 | 0.75 | ACP1 (0.52) | TSHRKDM4EGAAAURKA | |
| SCHEMBL3748349 | 0.74 | KCNH2 (0.63) | JAK1LMNAMAPTHTTKMT2A | |
| SCHEMBL7202162 | 0.73 | AURKA (0.45) | AURKA | |
| SCHEMBL7201841 | 0.73 | AURKA (0.43) | MAPTHTTNPSR1TSHRCASP1 | |
| SCHEMBL7203420 | 0.73 | ALDH1A1 (0.48) | MAPTHTTKMT2ATSHRKDM4E | |
| SCHEMBL8096295 | 0.72 | LMNA (0.58) | LMNAMAPTHTTKMT2ANPSR1 | |
| SCHEMBL7200373 | 0.72 | ACP1 (0.55) | LMNAMAPTHTTKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605617-B2 | Treating a patient in need of an inhibitor of vascular endothelial growth factor receptor tyrosine kinase | CHIRON CORPORATION | 2003-08-12 | — | — | US | disclosed |