Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 8/20 | 0.47 |
| ▸ | AURKA | O14965 | 6/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.47 |
| ▸ | PRKCG | P05129 | 5/20 | 0.47 |
| ▸ | PRKCB | P05771 | 5/20 | 0.47 |
| ▸ | PRKCA | P17252 | 5/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.47 |
| ▸ | PRKCH | P24723 | 5/20 | 0.47 |
| ▸ | CDK2 | P24941 | 5/20 | 0.47 |
| ▸ | PRKCI | P41743 | 5/20 | 0.47 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.47 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203775 | 0.88 | JAK1 (0.49) | JAK1CHEK1AURKA | |
| SCHEMBL7202162 | 0.79 | AURKA (0.45) | AURKAHTR6IRAK4 | |
| SCHEMBL7204767 | 0.79 | JAK1 (0.56) | JAK1AURKA | |
| SCHEMBL7201841 | 0.75 | AURKA (0.43) | AURKA | |
| SCHEMBL7206567 | 0.73 | ACP1 (0.52) | AURKA | |
| SCHEMBL1053495 | 0.73 | JAK1 (0.49) | JAK1CHEK1PRKCZAURKAPRKD3 | |
| SCHEMBL5308810 | 0.71 | AURKA (0.62) | AURKA | |
| SCHEMBL7203420 | 0.69 | ALDH1A1 (0.48) | AURKA | |
| SCHEMBL6388857 | 0.69 | CHEK1 (0.81) | JAK1CHEK1PRKCZAURKAPRKD3 | |
| SCHEMBL7200373 | 0.69 | ACP1 (0.55) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605617-B2 | Treating a patient in need of an inhibitor of vascular endothelial growth factor receptor tyrosine kinase | CHIRON CORPORATION | 2003-08-12 | — | — | US | disclosed |