Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 6/20 | 0.52 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7200373 | 0.85 | ACP1 (0.55) | ACP1HRH3AURKATSHRKDM4E | |
| SCHEMBL7201841 | 0.81 | AURKA (0.43) | ACP1AURKATSHRKDM4EHSD17B10 | |
| SCHEMBL7202162 | 0.77 | AURKA (0.45) | AURKA | |
| SCHEMBL7204767 | 0.75 | JAK1 (0.56) | AURKATSHRKDM4EGAA | |
| SCHEMBL7203420 | 0.74 | ALDH1A1 (0.48) | AURKATSHRKDM4EHSD17B10GAA | |
| SCHEMBL7203775 | 0.74 | JAK1 (0.49) | AURKA | |
| SCHEMBL8567589 | 0.73 | TSHR (0.78) | ACP1SMARCA2HRH3TSHRKDM4E | |
| SCHEMBL7199711 | 0.73 | JAK1 (0.52) | AURKA | |
| SCHEMBL4305912 | 0.73 | ACP1 (0.50) | ACP1SMARCA2HRH3KDM4EHSD17B10 | |
| SCHEMBL5308810 | 0.73 | AURKA (0.62) | AURKATSHRKDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605617-B2 | Treating a patient in need of an inhibitor of vascular endothelial growth factor receptor tyrosine kinase | CHIRON CORPORATION | 2003-08-12 | — | — | US | disclosed |