Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 9/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7199711 | 0.88 | JAK1 (0.52) | JAK1AURKACHEK1 | |
| SCHEMBL7204767 | 0.84 | JAK1 (0.56) | JAK1AURKAOPRM1OPRK1KCNH2 | |
| SCHEMBL5111478 | 0.79 | NR4A2 (0.51) | JAK1AURKACHEK1HTR3AOPRM1 | |
| SCHEMBL7202162 | 0.79 | AURKA (0.45) | AURKAPDGFRBFGFR1KDR | |
| SCHEMBL7201841 | 0.76 | AURKA (0.43) | AURKA | |
| SCHEMBL5308810 | 0.74 | AURKA (0.62) | AURKAPDGFRBKDR | |
| SCHEMBL7206567 | 0.74 | ACP1 (0.52) | AURKA | |
| SCHEMBL7203420 | 0.72 | ALDH1A1 (0.48) | AURKA | |
| SCHEMBL7086067 | 0.72 | FLT3 (0.44) | PDGFRBFGFR1KDRKCNH2 | |
| SCHEMBL7200373 | 0.71 | ACP1 (0.55) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605617-B2 | Treating a patient in need of an inhibitor of vascular endothelial growth factor receptor tyrosine kinase | CHIRON CORPORATION | 2003-08-12 | — | — | US | disclosed |