Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.59 |
| ▸ | CA1 | P00915 | 7/20 | 0.59 |
| ▸ | CA9 | Q16790 | 7/20 | 0.59 |
| ▸ | CA12 | O43570 | 4/20 | 0.59 |
| ▸ | CA5A | P35218 | 1/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | CA4 | P22748 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5615334 | 0.86 | TAAR1 (0.62) | LMNAALDH1A1 | |
| SCHEMBL14880664 | 0.84 | MAPT (0.48) | CA2CA1CA9CA12CA5A | |
| SCHEMBL2566108 | 0.81 | CA2 (0.57) | CA2CA1CA9CA12CA5A | |
| SCHEMBL7257652 | 0.80 | MRGPRX4 (0.51) | CA2CA1CA9CA12CA5A | |
| SCHEMBL2788591 | 0.79 | SMN1; SMN2 (0.69) | CA2CA1CA9CA12CA5A | |
| SCHEMBL7211055 | 0.79 | ALDH1A1 (0.46) | CA2CA1CA9CA5AKDM4E | |
| SCHEMBL13074347 | 0.76 | SMN1; SMN2 (0.85) | CA2CA1CA9CA12CA5A | |
| SCHEMBL16694535 | 0.76 | SMN1; SMN2 (0.60) | CA2CA1CA9CA12SMN1; SMN2 | |
| SCHEMBL10620436 | 0.76 | CA2 (0.61) | CA2CA1CA9CA12CA5A | |
| SCHEMBL2592712 | 0.75 | CA2 (0.60) | CA2CA1CA9CA12CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045690-B1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6162830-A | Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use | WARNER-LAMBERT COMPANY (US) | 2000-12-19 | — | — | US | disclosed |
| EP-1045690-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999026616-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1999-06-03 | — | — | WO | disclosed |