Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | THRB | P10828 | 2/20 | 0.66 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.66 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16983458 | 0.84 | ALDH1A1 (0.61) | ALDH1A1THRBABCC8KCNJ11CYP1A2 | |
| SCHEMBL28022581 | 0.82 | CA12 (0.45) | ALDH1A1THRBABCC8KCNJ11CYP1A2 | |
| SCHEMBL7950622 | 0.80 | ABCC8 (0.73) | ALDH1A1THRBABCC8KCNJ11CYP1A2 | |
| Diazoxide SCHEMBL31112206 | 0.80 | ABCC8 (1.00) | ALDH1A1THRBABCC8KCNJ11CYP1A2 | |
| Diazoxide SCHEMBL41255 | 0.80 | ABCC8 (1.00) | ALDH1A1THRBABCC8KCNJ11CYP1A2 | |
| SCHEMBL14095645 | 0.78 | CA12 (0.62) | ALDH1A1THRBCYP1A2CYP3A4SMN1; SMN2 | |
| SCHEMBL7952959 | 0.77 | ABCC8 (0.59) | ALDH1A1THRBABCC8KCNJ11CYP1A2 | |
| SCHEMBL7950864 | 0.76 | ABCC8 (0.66) | ALDH1A1THRBABCC8KCNJ11CYP1A2 | |
| SCHEMBL719010 | 0.75 | NPC1 (0.47) | ALDH1A1THRBABCC8KCNJ11CYP1A2 | |
| SCHEMBL7957631 | 0.75 | ABCC8 (0.57) | ALDH1A1THRBABCC8KCNJ11CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053172-A1 | USE OF A COMBINATION OF DIAZOXIDE AND METFORMIN FOR TREATING OBESITY OR OBESITY RELATED DISORDERS | COOPERATIEVE MIRZORG U.A. | 2012-03-01 | — | — | US | disclosed |
| US-20100234362-A1 | USE OF DIAZOXIDE FOR SUPPRESSING THE PLASMA INSULIN LEVEL IN A MAMMAL | COOPERATIEVE MIRZORG U.A. (NL) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053172-A1 | USE OF A COMBINATION OF DIAZOXIDE AND METFORMIN FOR TREATING OBESITY OR OBESITY RELATED DISORDERS | GPR119, KCNJ1, GLP1R | ALDH1A1 1266/4885THRB 647/4885ABCC8 317/4885 |
| US-20100234362-A1 | USE OF DIAZOXIDE FOR SUPPRESSING THE PLASMA INSULIN LEVEL IN A MAMMAL | KCNN4, KCNN1, GPR119 | ALDH1A1 1627/4885THRB 787/4885ABCC8 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.