Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.64 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7206689 | 0.86 | HTR6 (0.63) | HTR6KAT6AALDH1A1GHSRNR1I2 | |
| SCHEMBL7206683 | 0.84 | HTR6 (0.51) | HTR6KAT6AALDH1A1NR1I2POLB | |
| SCHEMBL3560333 | 0.79 | PTK2B (0.60) | HTR6KAT6AALDH1A1POLBMEN1 | |
| SCHEMBL3563292 | 0.78 | PTK2B (0.58) | HTR6KAT6AALDH1A1NR1I2MEN1 | |
| SCHEMBL12569386 | 0.78 | HTR6 (0.64) | HTR6GHSRSMN1; SMN2 | |
| SCHEMBL30737485 | 0.76 | HTR6 (0.62) | HTR6ALDH1A1POLBPKMMEN1 | |
| SCHEMBL28271803 | 0.76 | HTR6 (0.62) | HTR6ALDH1A1POLBPKMMEN1 | |
| SCHEMBL3554621 | 0.76 | PTK2B (0.50) | HTR6KAT6AALDH1A1NR1I2MEN1 | |
| SCHEMBL4370201 | 0.76 | HTR6 (0.66) | HTR6ALDH1A1GHSRPOLBSMN1; SMN2 | |
| Propane SCHEMBL7213474 | 0.76 | HTR6 (0.70) | HTR6ALDH1A1GHSRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077935-B1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | UPJOHN CO (US) | 2003-10-29 | — | — | EP | claimed |
| US-6103766-A | SUBSTITUTED OR UNSUBSTITUTED PHENYLSULFONAMIDE-PHENYLAMINE DERIVATIVES USEFUL FOR TREATING THE DISORDERS RELATED TO CENTRAL NERVOUS SYSTEM | PHARMACIA & UPJOHN COMPANY (US) | 2000-08-15 | — | — | US | claimed |
| EP-1077935-B1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | UPJOHN CO (US) | 2003-10-29 | — | — | EP | disclosed |
| US-6103766-A | SUBSTITUTED OR UNSUBSTITUTED PHENYLSULFONAMIDE-PHENYLAMINE DERIVATIVES USEFUL FOR TREATING THE DISORDERS RELATED TO CENTRAL NERVOUS SYSTEM | PHARMACIA & UPJOHN COMPANY (US) | 2000-08-15 | — | — | US | disclosed |