Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 8/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | HTR1B | P28222 | 8/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204648 | 0.94 | HTR1A (0.78) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7208815 | 0.94 | HTR1A (0.78) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8889776 | 0.85 | HTR1A (0.83) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL9412130 | 0.85 | HTR1A (0.83) | HTR1AHTR1DHTR1BDRD2 | |
| Oxalic Acid SCHEMBL7515265 | 0.83 | HTR1A (0.77) | HTR1AHTR1DHTR1BDRD2 | |
| Ly-293284 SCHEMBL7202815 | 0.82 | HTR1A (1.00) | HTR1AHTR1DHTR1BDRD2 | |
| Ly-293284 SCHEMBL6902000 | 0.82 | HTR1A (1.00) | HTR1AHTR1DHTR1BDRD2 | |
| Ly-293284 SCHEMBL7204055 | 0.82 | HTR1A (1.00) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL6364891 | 0.81 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7208944 | 0.81 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471576-B1 | 6-substituted-tetrahydrobenz[cd]indoles | LILLY CO ELI (US) | 2003-03-12 | — | — | EP | disclosed |