Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 12/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513657 | 0.86 | MAPT (0.56) | MAPTLMNAALDH1A1RAF1HPGD | |
| SCHEMBL14290088 | 0.86 | MAPT (0.64) | MAPTLMNAALDH1A1RAF1HPGD | |
| SCHEMBL5458467 | 0.86 | VCAM1 (0.49) | MAPTLMNAALDH1A1RAF1HPGD | |
| SCHEMBL6825768 | 0.83 | MAPT (0.56) | MAPTLMNAALDH1A1HPGDMAPK1 | |
| SCHEMBL11439028 | 0.83 | MAPT (0.50) | MAPTLMNAALDH1A1HPGDMAPK1 | |
| SCHEMBL4949648 | 0.82 | MAPT (0.62) | MAPTLMNAALDH1A1RAF1HPGD | |
| SCHEMBL1181285 | 0.81 | ALDH1A1 (0.44) | MAPTLMNAALDH1A1RAF1HPGD | |
| SCHEMBL5067747 | 0.81 | PIN1 (0.54) | VCAM1 | |
| SCHEMBL2969471 | 0.80 | ALDH1A1 (0.52) | MAPTLMNAALDH1A1HPGDMAPK1 | |
| SCHEMBL14453653 | 0.80 | KDM4E (0.56) | MAPTALDH1A1VCAM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923548-B1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A LIGANDS | WYETH CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-0923576-B1 | 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS | WYETH CORP (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-0923551-B1 | 4-AMINOETHOXY INDOLONE DERIVATIVES | AMERICAN HOME PROD (US) | 2002-06-05 | — | — | EP | disclosed |
| US-5958965-A | TREATMENT OF DISEASES ATTENDING DISTURBANCES IN THE SEROTINERGIC SYSTEMS, SUCH AS ANXIETY, STRESS, DEPRESSION, SEXUAL DYSFUNCTIONS AND SLEEP DISTURBANCES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0923576-A1 | 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | disclosed |
| EP-0923551-A1 | 4-AMINOETHOXY INDOLONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | disclosed |
| EP-0923548-A1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A? LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | disclosed |
| US-5817690-A | ANTIDOPAMINE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-10-06 | — | — | US | disclosed |
| US-5760070-A | TREATMENT OF PSYCHOLOGICAL DISORDERS, TOURETTE'S SYNDROME, ALCOHOL OR DRUG ADDICTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-06-02 | — | — | US | disclosed |
| WO-1998008819-A1 | 4-AMINOETHOXY INDOLONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-05 | — | — | WO | disclosed |
| WO-1998008843-A1 | 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-05 | — | — | WO | disclosed |
| WO-1998008817-A1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT1A LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-05 | — | — | WO | disclosed |