Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGD | P52209 | 3/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | PGK2 | P07205 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 9/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2239094 | 0.87 | PGK1 (0.45) | PGDPGK1PGK2MPIALDH1A1 | |
| Tromethamine SCHEMBL11584584 | 0.86 | PGD (0.35) | PGDPGK1PGK2MEN1LMNA | |
| SCHEMBL11601014 | 0.85 | PGK1 (0.43) | PGDPGK1PGK2MPIALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL11700135 | 0.85 | PGK1 (0.43) | PGDPGK1PGK2MPIALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL11596350 | 0.85 | PGK1 (0.43) | PGDPGK1PGK2MPIALDH1A1 | |
| Isopropylamine SCHEMBL11597104 | 0.81 | PGD (0.39) | PGDPGK1PGK2S1PR1S1PR3 | |
| Isopropylamine SCHEMBL11597106 | 0.81 | PGD (0.39) | PGDPGK1PGK2S1PR1S1PR3 | |
| Tromethamine SCHEMBL6755601 | 0.79 | PGD (0.35) | PGDPGK1PGK2MEN1LMNA | |
| Tromethamine SCHEMBL3421353 | 0.76 | MEN1 (0.40) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL1843995 | 0.75 | S1PR1 (0.40) | PGDPGK1PGK2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3497155-A1 | METHOD FOR PRODUCING EXPANDED GRANULAR MATERIAL | BASF SE (DE) | 2019-06-19 | — | — | EP | disclosed |
| EP-0927231-B1 | LOW DENSITY, LIGHT WEIGHT INTUMESCENT COATING | AKZO NOBEL NV (NL) | 2003-11-26 | — | — | EP | disclosed |
| US-6096812-A | EPOXY-BASED INTUMESCENT FIRE RESISTIVE COATING HAVING MINUTE PARTICLES OF AMORPHOUS SILICA DISPERSED THEREIN | TEXTRON SYSTEMS CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |
| US-4297138-A | USEFUL AS FLAME RETARDANTS | STAUFFER CHEMICAL COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| US-4225522-A | FIRE RETARDANTS | STAUFFER CHEMICAL COMPANY (US) | 1980-09-30 | — | — | US | disclosed |
| US-4086303-A | FIRE RETARDANTS | STAUFFER CHEMICAL COMPANY (US) | 1978-04-25 | — | — | US | disclosed |
| US-4080491-A | CATALYST CONTAINS ORGANOMETALLIC COMPOUND AND THE REACTION PRODUCT OF TUNGSTEN OR MOLYBDENUM OXIDE AND A PHOSPHOROUS HALIDE OR OXYHALIDE | SHOWA DENKO K.K. (JA) | 1978-03-21 | — | — | US | disclosed |