SCHEMBL7207553

SCHEMBL7207553

ClCCOc1ccc(Cl)c2[nH]ccc12

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 6/20 0.41
AHR P35869 1/20 0.34
RHEB Q15382 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HTR1A P08908 1/20 0.33
HTR1B P28222 1/20 0.33
AXL P30530 1/20 0.33
PRKCI P41743 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18702895 0.76 GPR84 (0.47) GPR84RHEBMAPTHPGDTDP1
SCHEMBL29503015 0.76 GPR84 (0.47) GPR84RHEBMAPTHPGDTDP1
SCHEMBL1013714 0.75 NR3C1 (0.40) AHRRHEBMEN1ALDH1A1MAPT
SCHEMBL7207549 0.75 DRD4 (0.64) KMT2A
SCHEMBL8527274 0.75 KMT2A (0.41) MEN1ALDH1A1MAPTHPGDKMT2A
SCHEMBL7207522 0.73 MEN1 (0.31) GPR84MEN1ALDH1A1LMNAMAPT
SCHEMBL2599781 0.71 AHR (0.48) AHRRHEBKMT2AAXLPRKCI
SCHEMBL6870381 0.71 EGFR (0.38) AHRRHEB
SCHEMBL4073823 0.71 HTR1B (0.60) RHEBMEN1ALDH1A1LMNAMAPT
SCHEMBL4238761 0.69 PRKCQ (0.42) GPR84RHEBMEN1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923548-B1 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A LIGANDS WYETH CORP (US) 2003-03-12 EP disclosed
EP-0923576-B1 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS WYETH CORP (US) 2002-11-06 EP disclosed
EP-0923551-B1 4-AMINOETHOXY INDOLONE DERIVATIVES AMERICAN HOME PROD (US) 2002-06-05 EP disclosed
CN-1077890-C 4-aminoethyoxy-indolone derivatives as dopamine D2 agonists AMERICAN HOME PROD (US) 2002-01-16 CN disclosed
CN-1234024-A 4-aminoethoxy indolone derivatives AMERICAN HOME PROD (US) 1999-11-03 CN disclosed
CN-1234033-A 4-aminoethoxy-indole derivatives as dopamine D2 agonists AMERICAN HOME PROD (US) 1999-11-03 CN disclosed
CN-1234023-A 4-aminoethoxy indoes as dopamin D2 agonists and as 5HT1A ligands AMERICAN HOME PROD (US) 1999-11-03 CN disclosed
US-5958965-A TREATMENT OF DISEASES ATTENDING DISTURBANCES IN THE SEROTINERGIC SYSTEMS, SUCH AS ANXIETY, STRESS, DEPRESSION, SEXUAL DYSFUNCTIONS AND SLEEP DISTURBANCES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-09-28 US disclosed
EP-0923576-A1 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-06-23 EP disclosed
EP-0923551-A1 4-AMINOETHOXY INDOLONE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-06-23 EP disclosed
EP-0923548-A1 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A? LIGANDS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-06-23 EP disclosed
US-5817690-A ANTIDOPAMINE AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-10-06 US disclosed
US-5760070-A TREATMENT OF PSYCHOLOGICAL DISORDERS, TOURETTE'S SYNDROME, ALCOHOL OR DRUG ADDICTION AMERICAN HOME PRODUCTS CORPORATION (US) 1998-06-02 US disclosed
WO-1998008819-A1 4-AMINOETHOXY INDOLONE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-05 WO disclosed
WO-1998008843-A1 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-05 WO disclosed
WO-1998008817-A1 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT1A LIGANDS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-05 WO disclosed