SCHEMBL7207522

SCHEMBL7207522

ClCCOc1ccc(Cl)c2[nH]cc(Cl)c12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.31
ALDH1A1 P00352 2/20 0.31
MAPT P10636 2/20 0.31
HPGD P15428 2/20 0.31
KMT2A Q03164 2/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
USP2 O75604 1/20 0.31
POLB P06746 1/20 0.31
CYP2C9 P11712 1/20 0.31
ALOX12 P18054 1/20 0.31
MAPK1 P28482 1/20 0.31
CYP2C19 P33261 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
LMNA P02545 1/20 0.31
HTT P42858 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
TRPA1 O75762 1/20 0.30
GPR84 Q9NQS5 1/20 0.30
HTR2A P28223 1/20 0.30
HTR2C P28335 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7482639 0.76 KMT2A (0.42) MEN1ALDH1A1KMT2AMAPK1CYP2C19
SCHEMBL7207966 0.75 KMT2A (0.51) KMT2APOLB
SCHEMBL7207553 0.73 GPR84 (0.41) MEN1ALDH1A1MAPTHPGDKMT2A
SCHEMBL7207516 0.73 ADRA1D (0.46) KMT2ACYP2C9CYP2C19
SCHEMBL7207584 0.72 DRD2 (0.47) ALDH1A1MAPTHPGDL3MBTL1MAPK1
SCHEMBL7474901 0.72 PPARG (0.39) MEN1ALDH1A1KMT2ACYP2C9CYP2C19
SCHEMBL8444963 0.72
SCHEMBL7467290 0.72
SCHEMBL8489503 0.71 CDC7 (0.30)
SCHEMBL7466886 0.70 TRPA1 (0.30) TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923548-B1 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A LIGANDS WYETH CORP (US) 2003-03-12 EP disclosed
EP-0923576-B1 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS WYETH CORP (US) 2002-11-06 EP disclosed
EP-0923551-B1 4-AMINOETHOXY INDOLONE DERIVATIVES AMERICAN HOME PROD (US) 2002-06-05 EP disclosed
CN-1077890-C 4-aminoethyoxy-indolone derivatives as dopamine D2 agonists AMERICAN HOME PROD (US) 2002-01-16 CN disclosed
CN-1234024-A 4-aminoethoxy indolone derivatives AMERICAN HOME PROD (US) 1999-11-03 CN disclosed
CN-1234023-A 4-aminoethoxy indoes as dopamin D2 agonists and as 5HT1A ligands AMERICAN HOME PROD (US) 1999-11-03 CN disclosed
CN-1234033-A 4-aminoethoxy-indole derivatives as dopamine D2 agonists AMERICAN HOME PROD (US) 1999-11-03 CN disclosed
US-5958965-A TREATMENT OF DISEASES ATTENDING DISTURBANCES IN THE SEROTINERGIC SYSTEMS, SUCH AS ANXIETY, STRESS, DEPRESSION, SEXUAL DYSFUNCTIONS AND SLEEP DISTURBANCES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-09-28 US disclosed
EP-0923576-A1 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-06-23 EP disclosed
EP-0923551-A1 4-AMINOETHOXY INDOLONE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-06-23 EP disclosed
EP-0923548-A1 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A? LIGANDS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-06-23 EP disclosed
US-5817690-A ANTIDOPAMINE AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-10-06 US disclosed
US-5760070-A TREATMENT OF PSYCHOLOGICAL DISORDERS, TOURETTE'S SYNDROME, ALCOHOL OR DRUG ADDICTION AMERICAN HOME PRODUCTS CORPORATION (US) 1998-06-02 US disclosed
WO-1998008843-A1 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-05 WO disclosed
WO-1998008819-A1 4-AMINOETHOXY INDOLONE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-05 WO disclosed
WO-1998008817-A1 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT1A LIGANDS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-05 WO disclosed