Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASE1 | P07998 | 1/20 | 0.37 |
| ▸ | TK2 | O00142 | 3/20 | 0.35 |
| ▸ | PLD2 | O14939 | 1/20 | 0.33 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.33 |
| ▸ | TK1 | P04183 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6831448 | 0.99 | TK2 (0.36) | RNASE1TK2PLD2PLD1TK1 | |
| SCHEMBL6836547 | 0.93 | MAPT (0.36) | RNASE1TP53MAPT | |
| SCHEMBL6834978 | 0.89 | RNASE1 (0.34) | RNASE1TK2TK1 | |
| SCHEMBL6831427 | 0.89 | RNASE1 (0.34) | RNASE1TK2TK1 | |
| SCHEMBL6834901 | 0.86 | RNASE1 (0.32) | RNASE1TK2TK1 | |
| SCHEMBL6831414 | 0.81 | TK1 (0.38) | TK2TK1 | |
| SCHEMBL6831419 | 0.81 | TK1 (0.38) | TK2TK1 | |
| SCHEMBL7207626 | 0.76 | TK2 (0.36) | TK2PLD2PLD1TK1 | |
| SCHEMBL17921691 | 0.74 | RNASE1 (0.40) | RNASE1TK2TK1 | |
| SCHEMBL2034479 | 0.74 | RNASE1 (0.38) | RNASE1TK2TK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610837-B1 | Preparation of an oligonucleotide compound of given formula by reacting with given compounds, followed by oxidation or sulfurization | ISIS PHARMACEUTICALS, INC. | 2003-08-26 | — | — | US | disclosed |