Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.77 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.77 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.77 |
| ▸ | MMP2 | P08253 | 8/20 | 0.77 |
| ▸ | MMP3 | P08254 | 8/20 | 0.77 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | MMP13 | P45452 | 3/20 | 0.64 |
| ▸ | MMP1 | P03956 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823156 | 0.87 | MMP2 (1.00) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL29160472 | 0.85 | ALDH1A1 (0.90) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7407018 | 0.81 | MMP13 (0.72) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7207560 | 0.81 | MMP13 (0.75) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL5702949 | 0.80 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| Hydroxyamine SCHEMBL8164284 | 0.80 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL7207037 | 0.79 | MMP1 (0.55) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL1429119 | 0.78 | KMT2A (0.60) | ALDH1A1TDP1LMNAKMT2AMEN1 | |
| SCHEMBL7208439 | 0.78 | MMP13 (1.00) | PDE4APDE4BPDE4CPDE4DMMP2 | |
| SCHEMBL15617705 | 0.77 | NPC1 (0.69) | PDE4APDE4BPDE4CPDE4DMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939628-B1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6013649-A | BOND DISORDERS; AUTOIMMUNE DISEASES; ANTITUMOR AGENTS | MONSANTO COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0939628-A4 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0939628-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998003164-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1998-01-29 | — | — | WO | disclosed |