Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211248 | 0.83 | LMNA (0.57) | LMNAHSD17B10SMN1; SMN2ALDH1A1CRHBP | |
| SCHEMBL6940776 | 0.82 | PPARA (0.43) | CHRM2CHRM4CHRM1CHRM3CYP2D6 | |
| SCHEMBL7207551 | 0.79 | L3MBTL1 (0.56) | LMNAHSD17B10SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL7211288 | 0.79 | PTGS2 (0.41) | LMNAHSD17B10PGRADRA2AADRA2B | |
| SCHEMBL7207786 | 0.77 | CHRM2 (0.41) | CHRM2CHRM4CHRM1CHRM3CYP2D6 | |
| SCHEMBL7206379 | 0.74 | LMNA (0.42) | LMNAHSD17B10SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL23872457 | 0.73 | CYP2D6 (0.61) | CHRM2CHRM4CHRM1CHRM3CYP2D6 | |
| SCHEMBL4921518 | 0.73 | CYP2D6 (0.61) | CHRM2CHRM4CHRM1CHRM3CYP2D6 | |
| SCHEMBL499471 | 0.73 | CYP2D6 (0.61) | CHRM2CHRM4CHRM1CHRM3CYP2D6 | |
| SCHEMBL2644175 | 0.71 | CHRM2 (0.52) | CHRM2CHRM4CHRM1CHRM3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |