Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 6/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.41 |
| ▸ | RELA | Q04206 | 6/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 12/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10740193 | 0.97 | NFKB1 (0.41) | NFKB1NFKB2RELALTB4RLTB4R2 | |
| SCHEMBL10512434 | 0.76 | CYP4F2 (0.55) | NFKB1NFKB2RELALTB4RLTB4R2 | |
| SCHEMBL4794533 | 0.75 | NFKB1 (0.41) | NFKB1NFKB2RELALTB4RLTB4R2 | |
| SCHEMBL7209043 | 0.73 | L3MBTL1 (0.35) | — | |
| SCHEMBL8048594 | 0.73 | NFKB1 (0.72) | NFKB1NFKB2RELA | |
| SCHEMBL23911581 | 0.72 | NFKB1 (0.41) | NFKB1NFKB2RELALTB4RLTB4R2 | |
| SCHEMBL10509049 | 0.70 | L3MBTL1 (0.35) | — | |
| SCHEMBL14457146 | 0.70 | LTB4R (0.45) | NFKB1NFKB2RELALTB4RLTB4R2 | |
| SCHEMBL8049427 | 0.69 | NFKB1 (0.39) | NFKB1NFKB2RELALTB4RLTB4R2 | |
| SCHEMBL10639016 | 0.69 | LTB4R (0.60) | LTB4RLTB4R2CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714396-B1 | VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-12-10 | — | — | EP | disclosed |
| US-6100268-A | MIGRAINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-08-08 | — | — | US | disclosed |