Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 8/20 | 0.53 |
| ▸ | CA2 | P00918 | 7/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869002 | 0.77 | NLRP3 (0.45) | NLRP3CA2 | |
| SCHEMBL7612982 | 0.76 | NLRP3 (0.90) | NLRP3CA2 | |
| SCHEMBL27430354 | 0.75 | NLRP3 (0.44) | NLRP3CA2 | |
| SCHEMBL191769 | 0.71 | GABRA1 (0.50) | CA2CA1 | |
| SCHEMBL6553324 | 0.69 | NLRP3 (1.00) | NLRP3CA2 | |
| SCHEMBL25033765 | 0.68 | NLRP3 (0.71) | NLRP3CA2 | |
| SCHEMBL7618158 | 0.67 | NLRP3 (0.35) | NLRP3CA2 | |
| Carbimide SCHEMBL29047475 | 0.67 | GABRA1 (0.46) | CA2CA1 | |
| Sulfanilamide SCHEMBL7658884 | 0.65 | CA2 (0.42) | NLRP3CA2CA12CA1CA9 | |
| SCHEMBL7622275 | 0.65 | NLRP3 (0.33) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964849-B1 | SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY | PFIZER (US) | 2003-06-04 | — | — | EP | disclosed |