Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 11/20 | 0.59 |
| ▸ | RARG | P13631 | 11/20 | 0.59 |
| ▸ | RARA | P10276 | 10/20 | 0.59 |
| ▸ | RXRA | P19793 | 13/20 | 0.50 |
| ▸ | HNF4A | P41235 | 3/20 | 0.50 |
| ▸ | RXRB | P28702 | 2/20 | 0.45 |
| ▸ | RXRG | P48443 | 2/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208528 | 1.00 | RARB (0.59) | RARBRARGRARARXRAHNF4A | |
| SCHEMBL6915722 | 0.87 | RARB (0.67) | RARBRARGRARARXRAHNF4A | |
| SCHEMBL7207880 | 0.85 | RARB (0.64) | RARBRARGRARARXRAHNF4A | |
| SCHEMBL7207884 | 0.85 | RARB (0.64) | RARBRARGRARARXRAHNF4A | |
| SCHEMBL6915866 | 0.85 | RARA (0.64) | RARBRARGRARARXRAHNF4A | |
| SCHEMBL8905707 | 0.84 | RXRA (0.43) | RARBRARGRARARXRAHNF4A | |
| SCHEMBL8905703 | 0.84 | RXRA (0.43) | RARBRARGRARARXRAHNF4A | |
| SCHEMBL7124972 | 0.83 | RARA (0.61) | RARBRARGRARARXRAHNF4A | |
| SCHEMBL7124980 | 0.83 | RARA (0.61) | RARBRARGRARARXRAHNF4A | |
| SCHEMBL6915189 | 0.82 | RARA (0.60) | RARBRARGRARARXRAHNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | claimed |
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | claimed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | claimed |
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | disclosed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | disclosed |