SCHEMBL7208708

SCHEMBL7208708

COc1ccc(NS(=O)(=O)c2ccccc2)c(C(=O)Nc2ccc(Cl)c(Cl)c2)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR27 Q9NS67 6/20 0.63
AVPR2 P30518 3/20 0.63
SLC20A2 Q08357 1/20 0.62
SLC20A1 Q8WUM9 1/20 0.62
KCNA5 P22460 1/20 0.54
MEN1 O00255 5/20 0.53
LMNA P02545 5/20 0.53
KMT2A Q03164 5/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
HPGD P15428 2/20 0.53
ALDH1A1 P00352 2/20 0.53
HTT P42858 2/20 0.53
KDM4E B2RXH2 2/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
CRHBP P24387 1/20 0.53
CYP2C19 P33261 1/20 0.53
CRHR2 Q13324 1/20 0.53
NOD2 Q9HC29 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7213175 0.86 SLC20A2 (0.54) GPR27AVPR2SLC20A2SLC20A1MEN1
SCHEMBL10249599 0.81 GPR27 (0.66) GPR27AVPR2SLC20A2SLC20A1KCNA5
SCHEMBL7209352 0.80 AVPR2 (0.59) GPR27AVPR2KCNA5MEN1LMNA
SCHEMBL6862230 0.80 SLC20A2 (0.66) GPR27AVPR2SLC20A2SLC20A1MEN1
SCHEMBL23200281 0.80 LMNA (0.63) GPR27AVPR2SLC20A2SLC20A1KCNA5
SCHEMBL29834293 0.80 LMNA (0.63) GPR27AVPR2SLC20A2SLC20A1KCNA5
SCHEMBL17530346 0.80 CYP2C9 (0.57) GPR27AVPR2SLC20A2SLC20A1MEN1
SCHEMBL5111324 0.79 SLC10A6 (0.69) GPR27AVPR2KCNA5MEN1LMNA
SCHEMBL7144951 0.79 GPR27 (0.70) GPR27AVPR2SLC20A2SLC20A1MEN1
SCHEMBL16270962 0.79 MAPT (0.61) GPR27AVPR2MEN1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP claimed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US claimed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP claimed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO claimed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO claimed
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP disclosed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US disclosed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP disclosed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO disclosed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO disclosed