SCHEMBL144223

SCHEMBL144223

Cc1ccc(C(=O)c2ccccc2Cl)c(O)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.57
KDM4E B2RXH2 3/20 0.57
RAB9A P51151 3/20 0.57
LMNA P02545 3/20 0.57
MEN1 O00255 2/20 0.57
ALDH1A1 P00352 4/20 0.49
GAA P10253 1/20 0.49
MAPT P10636 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
IDO1 P14902 2/20 0.49
TDO2 P48775 2/20 0.49
RECQL P46063 1/20 0.49
CYP1A2 P05177 1/20 0.47
PGR P06401 1/20 0.47
CYP3A4 P08684 1/20 0.47
ADORA3 P0DMS8 1/20 0.47
AR P10275 1/20 0.47
CHRM1 P11229 1/20 0.47
HPGD P15428 1/20 0.47
ALOX15 P16050 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7208739 0.88 RAB9A (0.59) KMT2AKDM4ERAB9ALMNAMEN1
SCHEMBL144475 0.87 KMT2A (0.70) KMT2AKDM4ERAB9ALMNAMEN1
SCHEMBL2167285 0.86 LMNA (0.62) KMT2AKDM4ERAB9ALMNAMEN1
SCHEMBL8459090 0.85 RAB9A (0.53) KMT2AKDM4ERAB9ALMNAMEN1
SCHEMBL30578000 0.84 NPC1 (0.56) KMT2AKDM4ERAB9ALMNAMEN1
SCHEMBL1758035 0.84 NPC1 (0.56) KMT2AKDM4ERAB9ALMNAMEN1
SCHEMBL11857097 0.83 MEN1 (0.61) KMT2AKDM4ELMNAMEN1ALDH1A1
SCHEMBL12909853 0.83 ALDH1A1 (0.51) KMT2ARAB9ALMNAMEN1ALDH1A1
SCHEMBL21550137 0.82 RAB9A (0.50) KMT2AKDM4ERAB9ALMNAMEN1
SCHEMBL9712419 0.82 KMT2A (0.52) KMT2AKDM4ERAB9ALMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2613819-B2 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2020-11-25 EP claimed
EP-2613819-B1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2018-01-10 EP claimed
CN-103209717-B Lubricious coatings for medical devices BIOINTERACTIONS LTD 2015-04-08 CN claimed
US-8541498-B2 Lubricious coatings for medical devices BIOINTERACTIONS LTD. (GB) 2013-09-24 US claimed
EP-2613819-A1 Lubricious coatings for medical devices Biointeractions Ltd. (GB) 2013-07-17 EP claimed
WO-2012032283-A1 Lubricious coatings for medical devices BIOINTERACTIONS LTD (GB) 2012-03-15 WO claimed
US-20120059111-A1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD. (GB) 2012-03-08 US claimed
EP-2613819-B2 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2020-11-25 EP disclosed
EP-2613819-B1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2018-01-10 EP disclosed
US-8541498-B2 Lubricious coatings for medical devices BIOINTERACTIONS LTD. (GB) 2013-09-24 US disclosed
EP-2613819-A1 Lubricious coatings for medical devices Biointeractions Ltd. (GB) 2013-07-17 EP disclosed
WO-2012032283-A1 Lubricious coatings for medical devices BIOINTERACTIONS LTD (GB) 2012-03-15 WO disclosed
US-20120059111-A1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD. (GB) 2012-03-08 US disclosed