SCHEMBL8459090

SCHEMBL8459090

Cc1ccc(C(=O)c2ccccc2Cl)c(C)c1

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.53
MAPK13 O15264 5/20 0.52
MAPK12 P53778 5/20 0.52
MAPK11 Q15759 5/20 0.52
MAPK14 Q16539 5/20 0.52
KMT2A Q03164 5/20 0.51
MEN1 O00255 3/20 0.51
KDM4E B2RXH2 1/20 0.51
LMNA P02545 1/20 0.51
RECQL P46063 1/20 0.50
CES2 O00748 1/20 0.47
CES1 P23141 1/20 0.47
NFE2L2 Q16236 1/20 0.46
ABCB1 P08183 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7208739 0.89 RAB9A (0.59) RAB9AMAPK13MAPK12MAPK11MAPK14
SCHEMBL9717031 0.86 ABCB1 (0.56) RAB9AMAPK13MAPK12MAPK11MAPK14
SCHEMBL11756227 0.85 MAPK13 (0.53) RAB9AMAPK13MAPK12MAPK11MAPK14
SCHEMBL144223 0.85 KMT2A (0.57) RAB9AMAPK13MAPK12MAPK11MAPK14
SCHEMBL14528312 0.83 MAPK13 (0.59) MAPK13MAPK12MAPK11MAPK14KMT2A
SCHEMBL21550137 0.83 RAB9A (0.50) RAB9AMAPK13MAPK12MAPK11MAPK14
SCHEMBL9712419 0.83 KMT2A (0.52) RAB9AMAPK13MAPK12MAPK11MAPK14
SCHEMBL286054 0.83 LMNA (0.50) RAB9AKMT2AMEN1LMNARECQL
SCHEMBL31369141 0.83 LMNA (0.50) RAB9AKMT2AMEN1LMNARECQL
SCHEMBL12303221 0.82 KMT2A (0.51) RAB9AMAPK13MAPK12MAPK11MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0713856-B1 Process for preparing brominated or chlorinated aromatic carboxylic acids CLARIANT GMBH (DE) 1999-09-08 EP disclosed
US-5637764-A Process for the preparation of brominated or chlorinated aromatic carboxylic acids HOECHST AKTIENGESELLSCHAFT (DE) 1997-06-10 US disclosed
EP-0713856-A1 Process for preparing brominated or chlorinated aromatic carboxylic acids HOECHST AKTIENGESELLSCHAFT (DE) 1996-05-29 EP disclosed
EP-0499450-A1 Synthesis of 1-aminoanthraquinone HOECHST CELANESE CORPORATION (US) 1992-08-19 EP disclosed
US-5130448-A Condensing ortho substituted benzoic acid and xylene, oxidation, ring closure, ammonolysis and decarboxyalation HOECHST CELANESE CORPORATION (US) 1992-07-14 US disclosed
US-4680402-A Benzoyl-phenyl-piperidine derivatives SOCIETE DE RECHERCHES INDUSTRIELLES (S.O.R.I.) (FR) 1987-07-14 US disclosed