Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 3/20 | 0.30 |
| ▸ | JAK2 | O60674 | 2/20 | 0.30 |
| ▸ | JAK1 | P23458 | 2/20 | 0.30 |
| ▸ | TYK2 | P29597 | 2/20 | 0.30 |
| ▸ | JAK3 | P52333 | 2/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL718683 | 0.84 | ALPL (0.34) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL1918402 | 0.76 | MEP1B (0.37) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL10255585 | 0.73 | DPP4 (0.45) | DHFRKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL2053323 | 0.71 | KLKB1 (0.39) | DHFRKDM4EHSD17B10LMNAMAPT | |
| SCHEMBL720879 | 0.70 | DPP4 (0.47) | DHFRKDM4EALDH1A1MAPTTLR7 | |
| SCHEMBL29556353 | 0.68 | KDM4E (0.33) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL16035178 | 0.68 | KDM4E (0.33) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL16075496 | 0.68 | ALPL (0.34) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL1480091 | 0.68 | ALPL (0.34) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL20727083 | 0.68 | DHPS (0.36) | DHFRKDM4EALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | DPYD, DHODH, TYMP | GABRA1 3353/4885GABRA5 3436/4885GABRA3 3556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.