Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | COASY | Q13057 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CBFB | Q13951 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209326 | 0.81 | RHEB (0.44) | HTTCOASYCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7114594 | 0.79 | CSNK2A2 (0.41) | HTTCOASYCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7122586 | 0.78 | CSNK2A2 (0.40) | HTTCOASYCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7208967 | 0.77 | ADORA1 (0.52) | COASYCSNK2A2CSNK2BCSNK2A1ADORA3 | |
| SCHEMBL7903051 | 0.77 | CSNK2A2 (0.49) | HTTCOASYCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL18922590 | 0.75 | HTT (0.61) | HTTCBFBHRH4ADORA3ADORA1 | |
| SCHEMBL29720357 | 0.73 | GAA (0.49) | HTTHRH4EGLN1KDM4EALDH1A1 | |
| SCHEMBL439758 | 0.73 | GAA (0.49) | HTTHRH4EGLN1KDM4EALDH1A1 | |
| SCHEMBL7120039 | 0.72 | CSNK2A2 (0.42) | HTTCOASYCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL24019958 | 0.72 | HRH4 (0.53) | HTTCBFBHRH4ADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617315-B1 | Sugar-substituted benzimidazole derivatives are used for the treatment or prophylaxis of restenosis, particularly following angioplasty | CHAMBERLAIN STANLEY DAWES (US) | 2003-09-09 | — | — | US | disclosed |
| US-6413938-B1 | HERPES VIRUS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2002-07-02 | — | — | US | disclosed |
| US-6204249-B1 | L-benzimidazole nucleosides | GLAXO WELLCOME INC. | 2001-03-20 | — | — | US | disclosed |
| EP-0970100-A1 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998035977-A1 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |