Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.51 |
| ▸ | COASY | Q13057 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 6/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045403 | 0.81 | CSNK2A2 (0.41) | ADORA1MAOBADORA2AADORA2BCOASY | |
| SCHEMBL21855798 | 0.78 | ADORA1 (0.56) | ADORA1MAOBADORA2AADORA2BPSMB8 | |
| SCHEMBL7208992 | 0.77 | HTT (0.56) | ADORA1COASYNR4A2CSNK2A2CSNK2B | |
| SCHEMBL1272228 | 0.75 | PSMB8 (0.51) | ADORA1MAOBADORA2AADORA2BPSMB8 | |
| SCHEMBL7209326 | 0.74 | RHEB (0.44) | COASYNR4A2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7114594 | 0.73 | CSNK2A2 (0.41) | COASYNR4A2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL11850373 | 0.73 | ADORA2A (0.65) | ADORA1MAOBADORA2AADORA2BPSMB8 | |
| SCHEMBL11989038 | 0.73 | ALDH1A1 (0.61) | KDM4EALDH1A1GAA | |
| SCHEMBL38664296 | 0.72 | PARP1 (0.60) | ADORA1MAOBADORA2AADORA2BPSMB8 | |
| SCHEMBL20252448 | 0.72 | PSMB8 (0.49) | ADORA1MAOBADORA2AADORA2BPSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617315-B1 | Sugar-substituted benzimidazole derivatives are used for the treatment or prophylaxis of restenosis, particularly following angioplasty | CHAMBERLAIN STANLEY DAWES (US) | 2003-09-09 | — | — | US | disclosed |
| US-6204249-B1 | L-benzimidazole nucleosides | GLAXO WELLCOME INC. | 2001-03-20 | — | — | US | disclosed |