SCHEMBL7209259

SCHEMBL7209259

CCOC(=O)c1ccc(NC(=O)c2ccccc2NS(=O)(=O)c2ccc(Cl)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.67
ALDH1A1 P00352 6/20 0.67
KMT2A Q03164 5/20 0.67
KDM4E B2RXH2 5/20 0.67
MEN1 O00255 4/20 0.67
SMN1; SMN2 Q16637 4/20 0.67
HTT P42858 4/20 0.67
HPGD P15428 3/20 0.67
CYP3A4 P08684 1/20 0.67
CYP2D6 P10635 1/20 0.67
CYP2C9 P11712 1/20 0.67
CRHBP P24387 1/20 0.67
CYP2C19 P33261 1/20 0.67
CRHR2 Q13324 1/20 0.67
NOD2 Q9HC29 1/20 0.67
BDKRB1 P46663 1/20 0.61
GAA P10253 3/20 0.58
NPC1 O15118 2/20 0.58
RAB9A P51151 1/20 0.58
TSHR P16473 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5120009 0.90 SLC10A6 (0.62) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL14267570 0.85 MEN1 (0.73) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL6861391 0.84 MEN1 (0.72) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL5118820 0.81 LMNA (0.58) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL23200270 0.81 LMNA (0.67) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL29834284 0.81 LMNA (0.67) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL5126247 0.81 KDM4E (0.65) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL5125023 0.80 MEN1 (0.69) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL2825316 0.80 LMNA (0.72) LMNAALDH1A1KMT2AKDM4EMEN1
SCHEMBL18375950 0.79 ALDH1A1 (0.67) LMNAALDH1A1KMT2AKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP claimed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US claimed
CN-1358062-A Macrophage scavenger receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-07-10 CN claimed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP claimed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO claimed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO claimed
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP disclosed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US disclosed
CN-1358062-A Macrophage scavenger receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-07-10 CN disclosed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP disclosed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO disclosed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO disclosed