Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | VCP | P55072 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TK1 | P04183 | 2/20 | 0.49 |
| ▸ | PNP | P00491 | 6/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HBB | P68871 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405149 | 0.80 | HPRT1 (0.47) | ALDH1A1LMNAPNPHPRT1 | |
| SCHEMBL19569930 | 0.79 | XDH (0.55) | MEN1KMT2ABLMTK1PNP | |
| Pyrimidine SCHEMBL28023221 | 0.78 | XDH (0.45) | MEN1KMT2ABLMALDH1A1LMNA | |
| SCHEMBL21137208 | 0.78 | XDH (0.55) | MEN1KMT2ABLMALDH1A1LMNA | |
| SCHEMBL21137720 | 0.77 | XDH (0.52) | MEN1KMT2ABLMTK1PNP | |
| SCHEMBL29138701 | 0.75 | XDH (0.48) | MEN1KMT2ABLMALDH1A1LMNA | |
| SCHEMBL9724912 | 0.75 | MEN1 (0.46) | MEN1KMT2ABLMALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL26629006 | 0.74 | PNP (0.50) | MEN1KMT2ABLMTK1PNP | |
| SCHEMBL874736 | 0.74 | PNP (0.64) | MEN1KMT2ABLMALDH1A1LMNA | |
| SCHEMBL7567095 | 0.73 | TK1 (0.60) | BLMTK1PNPUSP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334104-A2 | METHODS FOR TREATMENT OF DRUG-INDUCED PERIPHERAL NEUROPATHY AND RELATED CONDITIONS | Neotherapeutics, Inc. (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002004448-A2 | METHODS FOR TREATMENT OF DRUG-INDUCED PERIPHERAL NEUROPATHY AND RELATED CONDITIONS | NEOTHERAPEUTICS, INC. (US) | 2002-01-17 | — | — | WO | disclosed |