Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7197852 | 0.86 | SIRT2 (0.49) | CA2CA12CA1CA4CA7 | |
| SCHEMBL7293888 | 0.75 | CA12 (0.35) | CA2CA12CA1CA4CA7 | |
| SCHEMBL7303598 | 0.75 | CA12 (0.35) | CA2CA12CA1CA4CA7 | |
| SCHEMBL627191 | 0.74 | RAB9A (0.35) | CA2CA12CA1CA4CA7 | |
| SCHEMBL7201836 | 0.74 | CA12 (0.34) | CA2CA12CA1CA4CA7 | |
| SCHEMBL7296783 | 0.74 | DDB1 (0.37) | CA2CA12CA1CA4CA7 | |
| SCHEMBL1532744 | 0.73 | L3MBTL1 (0.39) | CA2CA12CA1CA4CA7 | |
| SCHEMBL4062089 | 0.73 | ALDH1A1 (0.46) | CA2CA12CA1CA4CA7 | |
| SCHEMBL7330474 | 0.72 | MAPT (0.33) | CA2CA12CA1CA4CA7 | |
| SCHEMBL2673236 | 0.71 | MAPT (0.50) | POLBUSP2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852226-B1 | PYRIMIDINE DERIVATIVES | KOWA CO (JP) | 2003-11-19 | — | — | EP | disclosed |
| US-5883092-A | Pyrimidine derivatives as endothelin antagonists | KOWA CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| EP-0852226-A1 | PYRIMIDINE DERIVATIVES | KOWA CO. LTD. (JP) | 1998-07-08 | — | — | EP | disclosed |