Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5666286 | 0.80 | RAB9A (0.35) | L3MBTL1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL9423732 | 0.79 | MEN1 (0.43) | RAB9AKDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7209808 | 0.73 | CA2 (0.46) | L3MBTL1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL627191 | 0.71 | RAB9A (0.35) | L3MBTL1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7197852 | 0.71 | SIRT2 (0.49) | RAB9AALDH1A1MAPTCA12CA1 | |
| SCHEMBL7295427 | 0.68 | PLAT (0.32) | L3MBTL1KDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7293888 | 0.64 | CA12 (0.35) | L3MBTL1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7303598 | 0.64 | CA12 (0.35) | RAB9AKDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13430583 | 0.63 | — | — | |
| SCHEMBL7296783 | 0.63 | DDB1 (0.37) | ALDH1A1CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841326-B1 | Process for the preparation of pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-05-16 | — | — | EP | claimed |
| US-6121447-A | STARTING WITH 2-CYANOPYRIMIDINE, WHICH IS PREPARED BY REACTING 2-CHLOROPYRIMIDINE WITH AN ALKALI CYANIDE IN THE PRESENCE OF 1-AZABICYCLO(2,2,2)OCTANE OR 1,4-DIAZABICYCLO(2,2,2)OCTANE | HOFFMANN-LA ROCHE INC. (US) | 2000-09-19 | — | — | US | claimed |
| EP-0841326-A1 | Process for the preparation of pyrimidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-13 | — | — | EP | claimed |
| WO-2013186706-A1 | PROCESS FOR THE PREPARATION OF BOSENTAN | CADILA PHARMACEUTICALS LTD (IN) | 2013-12-19 | — | — | WO | disclosed |
| WO-2011024056-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF BOSENTAN | AUROBINDO PHARMA LIMITED (IN) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011024056-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF BOSENTAN | AUROBINDO PHARMA LIMITED (IN) | 2011-03-03 | — | — | WO | disclosed |
| WO-2010015623-A1 | PROCESS FOR THE PREPARATION OF ENDOTHELIN RECEPTOR ANTAGONISTS | FARMAPROJECTS, S. A. (ES) | 2010-02-11 | — | — | WO | disclosed |
| EP-1137642-B1 | BIS-SULFONAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2007-12-05 | — | — | EP | disclosed |
| US-7285549-B2 | Sulfamides and their use as endothelin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-10-23 | — | — | US | disclosed |
| EP-1693372-A1 | Novel Sulfamides and their use as endothelin receptor antagonists | Actelion Pharmaceuticals Ltd. (CH) | 2006-08-23 | — | — | EP | disclosed |
| US-7094781-B2 | Sulfamides and their use as endothelin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2006-08-22 | — | — | US | disclosed |
| WO-2001017976-A1 | BIS-SULFONAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-03-15 | — | — | WO | disclosed |
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-6121447-A | STARTING WITH 2-CYANOPYRIMIDINE, WHICH IS PREPARED BY REACTING 2-CHLOROPYRIMIDINE WITH AN ALKALI CYANIDE IN THE PRESENCE OF 1-AZABICYCLO(2,2,2)OCTANE OR 1,4-DIAZABICYCLO(2,2,2)OCTANE | HOFFMANN-LA ROCHE INC. (US) | 2000-09-19 | — | — | US | disclosed |
| US-5883254-A | CYANATION OF PYRIMIDINES BY REACTING WITH AN ALKALI CYANIDE IN THE PRESENCE OF 1-AZABICYCLO(2,2,2)OCTANE OR 1,4-DIAZABICYCLO(2,2,2)OCTANE | HOFFMANN-LA ROCHE INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0841326-A1 | Process for the preparation of pyrimidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-13 | — | — | EP | disclosed |
| US-5420129-A | Treatment of hypertension, ischemia, vasospasms, angina | HOFFMANN-LA ROCHE INC. (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |