Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.56 |
| ▸ | IDO1 | P14902 | 6/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1145538 | 0.97 | LOXL2 (0.58) | LOXL2CYP2A6IDO1CYP19A1KCNJ1 | |
| SCHEMBL8734227 | 0.78 | LOXL2 (0.54) | LOXL2CYP2A6IDO1CYP19A1KCNJ1 | |
| Bromide SCHEMBL467284 | 0.77 | LOXL2 (0.58) | LOXL2CYP2A6IDO1CYP19A1KCNJ1 | |
| SCHEMBL1344068 | 0.76 | LOXL2 (0.65) | LOXL2CYP2A6IDO1CYP19A1KCNJ1 | |
| SCHEMBL1004267 | 0.76 | LOXL2 (0.64) | LOXL2CYP2A6IDO1CYP19A1KCNJ1 | |
| Bromide SCHEMBL6436882 | 0.75 | LOXL2 (0.95) | LOXL2CYP2A6IDO1CYP19A1KCNJ1 | |
| SCHEMBL22764103 | 0.75 | TSHR (0.55) | LOXL2CYP2A6IDO1CYP19A1KCNJ1 | |
| SCHEMBL45942 | 0.74 | CA2 (0.69) | LOXL2CYP2A6ALDH1A1CA12CA2 | |
| SCHEMBL127369 | 0.74 | IDO1 (0.69) | LOXL2IDO1ALDH1A1TSHR | |
| SCHEMBL2503454 | 0.74 | CA2 (0.69) | LOXL2CYP2A6ALDH1A1CA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974595-B1 | PROCESS FOR PRODUCING BORON COMPOUNDS | SHOWA DENKO KK (JP) | 2003-10-01 | — | — | EP | disclosed |