Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14701593 | 0.85 | ALDH1A1 (0.46) | ALDH1A1HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL23558942 | 0.82 | ALDH1A1 (0.44) | ALDH1A1HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL7158026 | 0.82 | ALDH1A1 (0.47) | ALDH1A1HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL30765878 | 0.82 | ALDH1A1 (0.47) | ALDH1A1HDAC1HDAC8HDAC6ENPP3 | |
| Hydrochloric Acid SCHEMBL30765949 | 0.81 | ALDH1A1 (0.46) | ALDH1A1HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL4033224 | 0.77 | ENPP3 (0.49) | ALDH1A1HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL7159207 | 0.72 | PPARG (0.47) | ALDH1A1ENPP3ENPP1NPC1RAB9A | |
| SCHEMBL3951956 | 0.71 | ENPP3 (0.53) | ALDH1A1HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL19378458 | 0.71 | HDAC1 (0.51) | ALDH1A1HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL30765823 | 0.70 | HDAC1 (0.39) | ALDH1A1HDAC1HDAC8HDAC6ENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617343-B1 | Treating non-insulin-dependent diabetes mellitus | ELI LILLY AND COMPANY | 2003-09-09 | — | — | US | claimed |
| EP-1214301-A1 | HYPOGLYCEMIC N,N-ARYLSULFONYLGLYCINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2002-06-19 | — | — | EP | claimed |
| WO-2001016119-A1 | HYPOGLYCEMIC N,N-ARYLSULFONYLGLYCINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-03-08 | — | — | WO | claimed |