Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169042 | 0.83 | ALDH1A1 (0.41) | ALDH1A1HPGDSMN1; SMN2TSHRLMNA | |
| SCHEMBL7212010 | 0.78 | ALDH1A1 (0.60) | ALDH1A1HPGDSMN1; SMN2TSHRLMNA | |
| SCHEMBL5512141 | 0.77 | TDP1 (0.61) | SMN1; SMN2TSHRMAPTHTTESR2 | |
| SCHEMBL7260199 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HPGDSMN1; SMN2TSHRLMNA | |
| SCHEMBL5282738 | 0.69 | ALDH1A1 (0.61) | ALDH1A1HPGDSMN1; SMN2TSHRLMNA | |
| SCHEMBL28830618 | 0.68 | NR1H3 (0.46) | ALDH1A1HPGDSMN1; SMN2TSHRLMNA | |
| SCHEMBL12077803 | 0.67 | ALDH1A1 (0.68) | ALDH1A1HPGDSMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL7652738 | 0.67 | ESR1 (0.55) | ALDH1A1HPGDSMN1; SMN2TSHRLMNA | |
| SCHEMBL5504401 | 0.67 | CNR2 (0.50) | TDP1KDM4E | |
| SCHEMBL7885963 | 0.66 | ALDH1A1 (0.61) | ALDH1A1HPGDSMN1; SMN2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610734-B2 | For therapy of Alzheimer's Disease and Down's syndrome | WYETH | 2003-08-26 | — | — | US | disclosed |