Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 6/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.74 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | TSHR | P16473 | 4/20 | 0.74 |
| ▸ | HPGD | P15428 | 4/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.74 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210520 | 0.98 | KDM4E (0.74) | KDM4ECYP2C9CYP1A2HSD17B10ABCB11 | |
| SCHEMBL29755877 | 0.92 | KDM4E (0.85) | KDM4ECYP2C9CYP1A2HSD17B10ABCB11 | |
| SCHEMBL3067467 | 0.92 | KDM4E (0.85) | KDM4ECYP2C9CYP1A2HSD17B10ABCB11 | |
| SCHEMBL29663663 | 0.88 | KDM4E (0.78) | KDM4ECYP2C9CYP1A2HSD17B10ABCB11 | |
| SCHEMBL820019 | 0.88 | KDM4E (0.78) | KDM4ECYP2C9CYP1A2HSD17B10ABCB11 | |
| SCHEMBL30872863 | 0.88 | KDM4E (0.78) | KDM4ECYP2C9CYP1A2HSD17B10ABCB11 | |
| SCHEMBL28376154 | 0.86 | KDM4E (0.76) | KDM4ECYP2C9CYP1A2HSD17B10ABCB11 | |
| Felodipine SCHEMBL26398 | 0.85 | CYP2C9 (1.00) | KDM4ECYP2C9CYP1A2HSD17B10ABCB11 | |
| Felodipine SCHEMBL13460298 | 0.85 | CYP2C9 (1.00) | KDM4ECYP2C9CYP1A2HSD17B10ABCB11 | |
| SCHEMBL7712188 | 0.85 | KDM4E (0.74) | KDM4ECYP2C9CYP1A2HSD17B10ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133473-B1 | NEW MANUFACTURING PROCESS | ASTRAZENECA AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| US-6350877-B1 | MANUFACTURE OF CLEVIDIPINE BY SALT FORMATION ESTERIFICATION | ASTRAZENECA AB (SE) | 2002-02-26 | — | — | US | disclosed |