Guanine

Guanine

SCHEMBL7211609

Nc1cc[nH]c(=O)n1.Nc1nc2nc[nH]c2c(=O)[nH]1.c1cncnc1

nearest known ligand 0.60

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Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PNP P00491 4/20 0.60
GRIA1 P42261 1/20 0.44
GRIA2 P42262 1/20 0.44
GRIA3 P42263 1/20 0.44
GRIA4 P48058 1/20 0.44
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
THRB P10828 1/20 0.40
HPGD P15428 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL2529420 0.92 PNP (0.72) PNPGRIA1GRIA2GRIA3GRIA4
Guanine SCHEMBL2528337 0.92 PNP (0.72) PNPGRIA1GRIA2GRIA3GRIA4
Guanine SCHEMBL79001 0.92 PNP (0.72) PNPGRIA1GRIA2GRIA3GRIA4
Guanine SCHEMBL8008324 0.91 PNP (0.50) PNPGRIA1GRIA2GRIA3GRIA4
Guanine SCHEMBL641789 0.88 PNP (0.79) PNPGRIA1GRIA2GRIA3GRIA4
Guanine SCHEMBL23576542 0.86 PNP (0.63) PNPGRIA1GRIA2GRIA3GRIA4
Guanine SCHEMBL37966 0.85 PNP (0.59) PNPKDM4EMEN1ALDH1A1MAPT
Guanine SCHEMBL19991865 0.85 PNP (0.62) PNPGRIA1GRIA2GRIA3GRIA4
Guanine SCHEMBL5579240 0.84 PNP (0.60) PNPGRIA1GRIA2GRIA3GRIA4
Guanine SCHEMBL28068968 0.81 PNP (0.63) PNPGRIA1GRIA2GRIA3GRIA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0742838-B1 METHODS FOR THE ELIMINATION OF DNA SEQUENCING ARTIFACTS UNIV CALIFORNIA (US) 2003-08-13 EP disclosed
US-20010051363-A1 Methods for the elimination of DNA sequencing artifacts CHAMBERLIN MICHAEL (US) 2001-12-13 US disclosed
US-6270962-B1 DECREASING INCIDENCE OF DNA(DEOXYRIBO NUCLEIC ACID) POLYMERASE STOPS OR PAUSING OCCURRING IN A REACTION MIXTURE CONTAINING A DNA POLYMERASE BY ADDING NITROGEN CONTAINING ORGANIC COMPOUNDS (E.G: BETAINE, TRIMETHYLAMINE N-OXIDE, ETC) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2001-08-07 US disclosed